Dyofertia 20 is a high strength progestogen tablet that is composed of Dydrogesterone 20mg per tablet. It is the higher dose solution in the Dyofertia range and is prescribed when a stronger progestogenic effect is clinically needed specifically in conditions that involve hormonal imbalance or higher risk pregnancy support cases.
Dydrogesterone is a structurally unique and orally active form of natural progesterone which has been used in clinical practice for more than 50 years. It is one of the most reliable progestogens in gynaecology and reproductive medicine. Dyofertia 20 is manufactured under WHO-GMP certified manufacturing standards to make sure there is constant quality in every blister pack.
How Dydrogesterone 20mg Works?
Dydrogesterone carefully combines with high affinity to progesterone receptors in the uterus. It imposes a targeted progestonic effect without any interaction with any receptors. This receptor selectivity showcases its favourable tolerability profile even at the 20mg dose.
At the endometrial level, Dydrogesterone promotes the transformation from a proliferative to a secretory state, a critical step in preparing the uterine lining for embryo implantation and sustaining early pregnancy. It also plays an immunomodulatory role, modulating the maternal immune response to reduce the risk of rejection of the implanted embryo, which is particularly relevant in recurrent pregnancy loss.
Therapeutic Indications
Dyofertia-20 (Dydrogesterone 20mg) is indicated for conditions requiring stronger progestogenic support, including:
- Recurrent and habitual miscarriage, higher-dose protocol
- Threatened miscarriage with significant hormonal deficit
- Moderate to severe endometriosis
- Luteal phase insufficiency during ART cycles (IVF/IUI)
- Dysfunctional uterine bleeding unresponsive to lower doses
- Secondary amenorrhoea and irregular menstrual cycles
- Premenstrual syndrome (PMS), severe presentations
- Hormone replacement therapy (HRT), higher progestogenic component
Dosage & Administration
Dyofertia-20 tablets are taken orally, with or without food. The dose, frequency, and duration of treatment are determined entirely by the treating gynaecologist or obstetrician based on the specific clinical indication and the patient’s response. Typical regimens may involve a single 20mg tablet daily or divided doses across specific phases of the menstrual cycle or throughout the first trimester of pregnancy. Patients should not self-adjust the dose without medical guidance.
Safety & Tolerability
The 20mg dose of Dydrogesterone maintains the same favourable receptor selectivity as the 10mg formulation, with no androgenic activity and no known risk of virilisation of the female foetus. It does not suppress ovulation at standard therapeutic doses and has no significant impact on lipid or carbohydrate metabolism, making it appropriate for a wide patient population.
Side effects are generally mild and may include headache, nausea, breast tenderness, or occasional breakthrough bleeding, particularly at the initiation of therapy. Dyofertia-20 is contraindicated in patients with known or suspected progesterone-sensitive malignancies, undiagnosed abnormal uterine bleeding, severe hepatic impairment, or hypersensitivity to Dydrogesterone or any of its excipients. Use only under medical supervision.
Why Choose Dyofertia-20 by Aunexis Pharmaceuticals?
- Double-strength 20mg formulation for cases requiring robust progestogenic support
- WHO-GMP certified manufacturing ensuring purity, potency, and consistency
- Identical receptor selectivity to the 10mg variant, no additional adverse receptor activity
- Convenient 10×1×10 blister pack for accurate dispensing and patient compliance
- Part of a trusted gynaecology-focused pharmaceutical portfolio from Aunexis
Frequently Asked Questions
Q1. What is Dyofertia-20 and how does it differ from Dyofertia-10?
Dyofertia-20 contains Dydrogesterone 20mg, double the strength of Dyofertia-10, prescribed for conditions requiring stronger or sustained progestogenic support.
Q2. What conditions is Dyofertia-20 prescribed for?
It is used for recurrent miscarriage, threatened abortion, severe endometriosis, luteal phase insufficiency, ART support, dysfunctional uterine bleeding, and HRT.
Q3. Is Dyofertia-20 safe to use during pregnancy?
Yes, under medical supervision. Dydrogesterone has no virilising effect on the foetus and is widely used for pregnancy support in the first trimester.
Q4. Does Dydrogesterone 20mg suppress ovulation?
No. Even at 20mg, Dydrogesterone does not suppress ovulation, making it suitable for women undergoing fertility treatment or trying to conceive.
Q5. Why would a doctor prescribe 20mg instead of 10mg?
A 20mg dose is prescribed when a stronger progestogenic effect is needed, such as in severe endometriosis, higher-risk pregnancies, or recurrent miscarriage protocols.
